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Manufacturing is undergoing a digital revolution, yet many transformation initiatives stall due to a fundamental problem: data trapped in silos. The real roadblock isn't AI or lack of tools, but interoperability—the ability of systems, teams, and companies to understand and trust each other's data. This article explores why traditional approaches fail and introduces Manufacturing Data Spaces as the missing foundation. Data Spaces provide a secure, sovereign framework for controlled data sharing across plants and partners—without giving up ownership. From energy efficiency to predictive maintenance and compliance reporting, real-world examples show how manufacturers can unlock value while preserving control. We explore the layers of interoperability, human concerns, key enabling technologies like AAS and OPC UA, and how to get started with pilots that deliver real ROI. For manufacturers, building trust-based data collaboration isn’t just a tech upgrade—it’s a strategic move that defines future competitiveness in an increasingly connected industry.